How prenatal exposure to certain chemicals and diet affects obesity across generations
Interactions between prenatal obesogen exposure and Total Western diet lead to a transgenerational thrifty phenotype: functional and epigenomic analysis of effects in fat and liver
This study is looking at how certain chemicals in the environment during pregnancy, along with a typical Western diet, might lead to obesity and health problems in future generations, and it aims to find out how these factors affect fat and liver function to help develop better ways to prevent and treat obesity-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11191204 on NIH RePORTER |
What this research studies
This research investigates how exposure to specific environmental chemicals during pregnancy, combined with a typical Western diet, can lead to obesity and related health issues in future generations. The study focuses on understanding the biological mechanisms behind these effects, particularly through analyzing changes in fat and liver function. By examining the genetic and epigenetic changes that occur, the research aims to uncover how these factors contribute to obesity and metabolic disorders. Patients may benefit from insights that could lead to new prevention and treatment strategies for obesity-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a family history of obesity or metabolic disorders and are interested in understanding the impact of prenatal exposures on health.
Not a fit: Patients who do not have a family history of obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for preventing obesity and its related health issues in future generations.
How similar studies have performed: Other research has shown success in linking environmental exposures to obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Blumberg, Bruce — University of California-Irvine
- Study coordinator: Blumberg, Bruce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.