How prenatal corticosteroids affect the gut microbiome of newborns.
Perinatal Precursors of Early Microbiome Development.
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10654730
This study is looking at how medications given to pregnant women at risk of having a premature baby might change the tiny bacteria in their newborns' guts, and it also wants to see how the mother's stress and mental health could play a part in this.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10654730 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of prenatal exposure to corticosteroids on the gut microbiome of newborns. It focuses on understanding how these medications, often given to mothers at risk of preterm birth, may alter the microbial communities in infants, potentially leading to adverse health outcomes. The study also examines the role of maternal mental health, particularly depression and stress, in shaping the infant's microbiome. By analyzing the differences in microbial composition between infants born to mothers who received corticosteroids and those who did not, the research aims to uncover critical insights into early microbial development.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women at risk of preterm birth who may be prescribed corticosteroids.
Not a fit: Patients who are not pregnant or those who are not at risk of preterm birth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved guidelines for the use of corticosteroids in pregnant women, enhancing neonatal health outcomes.
How similar studies have performed: Previous research has indicated significant effects of prenatal corticosteroid exposure on neonatal health, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, SANDRA JEAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: WEISS, SANDRA JEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.