How prenatal alcohol exposure affects brain signaling and behavior
Role of Microglia in Prenatal ethanol exposure-induced Impairment of Endocannabinoid Signaling
This study is looking at how drinking alcohol during pregnancy affects the brain development of babies, especially how it impacts certain brain cells and signals that help with thinking and behavior, to find ways to help kids with fetal alcohol spectrum disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10870042 on NIH RePORTER |
What this research studies
This research investigates the impact of prenatal alcohol exposure on brain development and function, particularly focusing on how it affects microglia and endocannabinoid signaling. The study aims to understand the mechanisms behind cognitive and behavioral deficits associated with fetal alcohol spectrum disorders (FASD). By examining the role of microglial activation and its influence on synaptic functions, the research seeks to identify potential interventions that could improve outcomes for affected individuals. The methodology includes using animal models to explore the relationship between prenatal alcohol exposure, microglial activity, and behavioral changes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals under 21 years old who have been diagnosed with fetal alcohol spectrum disorders or exhibit related cognitive and behavioral challenges.
Not a fit: Patients who do not have a history of prenatal alcohol exposure or do not exhibit cognitive or behavioral deficits related to fetal alcohol spectrum disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognitive and behavioral outcomes in individuals affected by fetal alcohol spectrum disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia and endocannabinoid signaling in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Shen, Roh-Yu — State University of New York at Buffalo
- Study coordinator: Shen, Roh-Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.