How preanalytical factors affect prostate cancer biopsy results
Prostate Needle Biopsies: Impact of Preanalytical Procurement and Processing Variables on the Detection of Gene Expression Signatures of Prostate Cancer Aggressiveness
This study is looking at how different ways of collecting and preparing tissue samples can affect the accuracy of tests that show how aggressive prostate cancer might be, with the goal of helping doctors make better treatment decisions for patients getting prostate biopsies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11136995 on NIH RePORTER |
What this research studies
This research investigates how various preanalytical factors, such as tissue procurement and processing, influence the detection of gene expression signatures that indicate the aggressiveness of prostate cancer. By focusing on optimizing these conditions, the study aims to improve the accuracy of risk assessments for patients undergoing prostate biopsies. The research will utilize advanced techniques, including multiparametric MRI guidance, to ensure that biopsy samples are handled correctly from collection to analysis. This could lead to better-informed treatment decisions for patients diagnosed with prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men who are undergoing prostate biopsies for suspected prostate cancer.
Not a fit: Patients who have already been diagnosed with advanced prostate cancer and are not undergoing biopsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the precision of prostate cancer risk assessments, leading to more tailored and effective treatment strategies for patients.
How similar studies have performed: Previous research has shown that optimizing preanalytical conditions can significantly improve the reliability of diagnostic tests, suggesting that this approach may yield beneficial results.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pollack, Alan — University of Miami School of Medicine
- Study coordinator: Pollack, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.