How pre-existing allergies affect respiratory viral infections in children and older adults
Official title: Pre-Existing Atopy and Respiratory Viral Infections
Funded at Research Inst Nationwide Children's Hosp · NIH-11012389 · Data updated 2026-11-12
This study is looking at how having allergies might help protect young children and older adults from getting really sick from respiratory viruses like RSV, using mice to learn more about how the immune system works in these cases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | February 24, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $699,487 |
| NIH project number | 5R01AI171027-03 |
| Project ID | NIH-11012389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 5 years old and adults aged 65 and older who have a history of allergies.
✕Less likely to help
Patients without a history of allergies or those who do not fall within the specified age groups may not benefit from this research.
What this research studies
This research investigates the relationship between pre-existing allergies (atopy) and the severity of respiratory viral infections, particularly focusing on respiratory syncytial virus (RSV) in children under 5 and older adults over 65. The study utilizes mouse models to explore how atopy may provide a protective effect against severe outcomes from viral infections. By examining immune responses and specific cellular mechanisms, the research aims to uncover how allergies might influence the body's ability to combat respiratory viruses. The findings could lead to new insights into treatment and prevention strategies for vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for respiratory viral infections, potentially reducing hospitalizations and mortality rates in children and older adults.
How similar studies have gone: Previous studies have indicated that pre-existing atopy may offer protective effects against severe viral infections, suggesting that this research builds on established findings.
Where this research is happening
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Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Grayson, Mitchell H — Research Inst Nationwide Children's Hosp
- Study coordinator: Grayson, Mitchell H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.