How poxviruses manipulate cell division and immune responses
Official title: Subversion of Cellular Mitotic and Antiviral Signaling by Poxviral Kinases
Funded at University of Nebraska Lincoln · NIH-10978213 · Data updated 2026-11-12
This study is looking at how certain viruses, called poxviruses, mess with the way our cells divide and fight off infections, and it’s for anyone interested in understanding how these viruses can outsmart our immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | December 3, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $434,022 |
| NIH project number | 5R01AI165501-03 |
| Project ID | NIH-10978213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with viral infections, particularly those caused by poxviruses or related pathogens.
✕Less likely to help
Patients with non-viral infections or those not affected by poxviruses may not benefit from this research.
What this research studies
This research investigates how poxviruses affect the cellular processes that control cell division and the body's antiviral responses. By studying specific proteins produced by these viruses, the researchers aim to understand how these proteins interfere with normal cellular signaling pathways. This could reveal new insights into viral infections and how they evade the immune system. The approach involves comparing viral proteins with similar proteins found in human cells to uncover their mechanisms of action.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating viral infections and enhancing antiviral responses in patients.
How similar studies have gone: Other research has shown promise in understanding viral manipulation of cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Wiebe, Matthew S — University of Nebraska Lincoln
- Study coordinator: Wiebe, Matthew S
Related research
Other NIH-funded projects on the same topics.
-
Identify Unknowns with Long-Read Bioinformatics for Vet Diagnostic Labs
A hands-on training program using long-read sequencing data to help veterinary diagnostic labs improve pathogen detection and outbreak response.
-
Enhancing pathogen and AMR detection with a new sequencing instrument
A veterinary lab is getting a high-throughput sequencing machine to help detect drug-resistant bacteria and emerging pathogens in animals and food, improving public health readiness.
-
How childhood hardship and neighborhood features affect adult alcohol and tobacco misuse
This project looks at whether adults who experienced tough childhoods are more likely to misuse alcohol or tobacco later in life and whether where they live makes that risk higher or lower.
-
Nicotine's effect on drinking sweetened alcoholic drinks
This project looks at whether nicotine makes people drink more sweetened alcoholic drinks, especially among people who smoke or drink heavily.
-
MiRNA roles in age-related muscle loss and NMJ health
This project explores how small RNA molecules called miRNAs influence muscle aging and the neuromuscular junction in adults.
-
MG53 protein to protect aging muscles during disuse
A small research project will explore whether increasing MG53 protein can help prevent muscle loss during periods of inactivity in aging, with the goal of protecting muscle health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.