How potassium channels affect blood vessels in pregnant women with long QT syndrome
Official title: Potassium channels and uteroplacental vessels function in pregnant long QT type 1 women
Funded at University of Colorado Denver · NIH-10802387 · Data updated 2026-11-12
This study is looking at how certain channels in the blood vessels of pregnant women with long QT syndrome type 1 affect blood flow to the placenta, which is important for the baby's growth, and it aims to find ways to help improve pregnancy outcomes for these women.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 8, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21HD109564-02 |
| Project ID | NIH-10802387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women diagnosed with long QT syndrome type 1.
✕Less likely to help
Patients without long QT syndrome or those not currently pregnant may not benefit from this research.
What this research studies
This research investigates the role of potassium channels in the blood vessels of pregnant women who have long QT syndrome type 1. It focuses on how these channels may influence blood flow to the placenta, which is crucial for fetal development. The study will compare the function of these channels in women with long QT syndrome to those without, aiming to understand how impaired blood vessel function could lead to complications like fetal growth restriction or miscarriage. By examining these mechanisms, the research seeks to identify potential interventions to improve pregnancy outcomes for affected women.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for pregnant women with long QT syndrome, potentially reducing the risk of miscarriage and fetal growth issues.
How similar studies have gone: Previous research has shown that understanding the role of potassium channels in vascular function can lead to significant insights in pregnancy complications, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Lorca, Ramon a — University of Colorado Denver
- Study coordinator: Lorca, Ramon a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.