How poliovirus reshapes cell membranes to make more viruses
Picornavirus Genome Replication
Researchers are learning how poliovirus changes the fats inside human cells so people with polio or related infections might one day get better treatments.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11285310 on NIH RePORTER |
What this research studies
This project looks at how poliovirus reprograms the lipids and membranes in human cells to create sites for viral genome replication. The team focuses on viral proteins such as 3CD and host regulators like c-Fos to identify key steps that the virus co-opts. They use lab-grown human cells, lipid biochemistry, and advanced imaging to track membrane and phospholipid changes during infection. By mapping these processes, the researchers aim to reveal host factors and lipid enzymes that could be targeted to stop viral replication.
Who could benefit from this research
Good fit: People affected by polio or other enterovirus infections, or those willing to donate blood or tissue samples, would be most relevant to this work.
Not a fit: People with conditions unrelated to poliovirus or enteroviruses are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could identify new drug targets or strategies to block poliovirus and related enterovirus infections.
How similar studies have performed: Prior lab studies have shown many RNA viruses remodel host membranes and have identified some viral and host players, but this project aims to provide deeper, novel mechanistic detail.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Cameron, Craig E. — Univ of North Carolina Chapel Hill
- Study coordinator: Cameron, Craig E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.