How pneumonia affects the brain's blood vessels
Official title: Nosocomial pneumonia impairs the cerebrovasculature
Funded at University of South Alabama · NIH-11090567 · Data updated 2026-11-12
This study is looking at how pneumonia can affect the brain and memory in people who have survived the infection, with the goal of finding ways to help prevent thinking problems later on.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | May 16, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $671,026 |
| NIH project number | 5R01NS135147-02 |
| Project ID | NIH-11090567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced pneumonia, particularly those with a history of cognitive issues or who are at risk for dementia.
✕Less likely to help
Patients who have not had pneumonia or those with pre-existing severe cognitive impairments unrelated to pneumonia may not benefit from this research.
What this research studies
This research investigates the impact of pneumonia on the cerebrovasculature, particularly focusing on how pneumonia-related infections can lead to cognitive deficits in survivors. It examines the mechanisms by which lung infections trigger the production of harmful proteins that can accumulate in the brain, potentially leading to conditions like dementia. The study utilizes advanced imaging techniques to observe changes in blood flow and brain structure in response to pneumonia. By understanding these processes, the research aims to identify potential therapeutic targets to mitigate cognitive decline in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline in patients who have suffered from pneumonia.
How similar studies have gone: There is growing evidence from other studies that suggest similar mechanisms of cognitive decline following infections, indicating that this research builds on established findings.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Nelson, Amy R — University of South Alabama
- Study coordinator: Nelson, Amy R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.