How platelets help blood clots contract in the mouth
Official title: Multiscale structural and functional biomechanics of contracting platelet-fibrin based biomaterials and blood clots in oral microenvironment
Funded at Virginia Polytechnic Inst and St Univ · NIH-10905618 · Data updated 2026-11-12
This study is looking at how platelets help blood clots shrink and heal after dental surgeries, so we can better understand how to improve recovery for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | August 11, 2023 |
| Project end | September 21, 2025 |
| Funding year | 2022 |
| Award (this year) | $149,085 |
| NIH project number | 7R21DE030294-03 |
| Project ID | NIH-10905618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are scheduled for oral or dental surgical procedures.
✕Less likely to help
Patients with conditions that prevent them from undergoing dental procedures may not benefit from this research.
What this research studies
This research investigates the role of platelets in the contraction of blood clots and fibrin matrices in the oral environment, particularly after dental surgeries. By examining the biomechanical interactions between activated platelets and fibrin, the study aims to understand how these processes contribute to wound healing and tissue regeneration. The research will utilize advanced techniques to analyze the dynamics of clot contraction over time, providing insights into how these mechanisms can improve healing outcomes for patients undergoing oral procedures.
Why it matters
Potential benefit: If successful, this research could enhance wound healing and tissue regeneration in patients undergoing dental surgeries.
How similar studies have gone: While the biochemical aspects of platelet function have been studied, the specific biomechanical interactions in the oral environment are less explored, making this research a novel investigation.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Kim, Oleg — Virginia Polytechnic Inst and St Univ
- Study coordinator: Kim, Oleg
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.