How platelets affect the lung environment in breast cancer spread
Official title: The Role of Platelets in Establishing the Lung Pre-Metastatic Niche in Breast Cancer
Funded at Brigham and Women's Hospital · NIH-10894750 · Data updated 2026-11-12
This study is looking at how platelets in the blood help create a friendly environment in the lungs for breast cancer cells to spread, with the hope of finding new ways to stop this from happening and help patients avoid the cancer spreading further.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $178,200 |
| NIH project number | 5K99CA283008-02 |
| Project ID | NIH-10894750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer patients who are at risk of developing metastatic disease.
✕Less likely to help
Patients with non-breast cancers or those who are not at risk for metastasis may not benefit from this research.
What this research studies
This research investigates how platelets contribute to the formation of a supportive environment in the lungs that allows breast cancer cells to spread. It aims to understand the mechanisms by which platelets influence this pre-metastatic niche, which is a critical step in the progression of breast cancer. By examining the interactions between platelets and immune cells in the lung, the study seeks to identify potential therapeutic targets to prevent metastasis. Patients may benefit from insights that could lead to new preventive strategies against breast cancer spread.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent breast cancer from spreading to the lungs.
How similar studies have gone: Other research has shown that targeting the pre-metastatic niche can be effective, suggesting that this approach may yield promising results.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Roweth, Harvey George — Brigham and Women's Hospital
- Study coordinator: Roweth, Harvey George
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.