How platelets affect the lung environment in breast cancer spread
The Role of Platelets in Establishing the Lung Pre-Metastatic Niche in Breast Cancer
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10894750
This study is looking at how platelets in the blood help create a friendly environment in the lungs for breast cancer cells to spread, with the hope of finding new ways to stop this from happening and help patients avoid the cancer spreading further.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10894750 on ClinicalTrials.gov |
What this research studies
This research investigates how platelets contribute to the formation of a supportive environment in the lungs that allows breast cancer cells to spread. It aims to understand the mechanisms by which platelets influence this pre-metastatic niche, which is a critical step in the progression of breast cancer. By examining the interactions between platelets and immune cells in the lung, the study seeks to identify potential therapeutic targets to prevent metastasis. Patients may benefit from insights that could lead to new preventive strategies against breast cancer spread.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who are at risk of developing metastatic disease.
Not a fit: Patients with non-breast cancers or those who are not at risk for metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent breast cancer from spreading to the lungs.
How similar studies have performed: Other research has shown that targeting the pre-metastatic niche can be effective, suggesting that this approach may yield promising results.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROWETH, HARVEY GEORGE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ROWETH, HARVEY GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.