How platelets affect brain injury after a stroke
Platelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke Injury
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11169374
This study is looking at how certain blood cells, called platelets and neutrophils, can cause damage during strokes when blood flow to the brain is blocked, and it aims to find new ways to help stroke patients recover better by testing a new treatment that stops a harmful process these cells create.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11169374 on ClinicalTrials.gov |
What this research studies
This research investigates the role of platelets and neutrophils in causing damage during ischemic strokes, which occur when blood flow to the brain is blocked. The study aims to understand how these blood cells interact and contribute to stroke injury, particularly focusing on a process called neutrophil extracellular trap (NET) formation. By exploring the mechanisms behind NET release and its effects on stroke outcomes, the researchers hope to identify new therapeutic targets that could improve recovery for stroke patients. The approach includes laboratory experiments and animal models to test the effectiveness of a novel treatment that inhibits NET formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are seeking new treatment options.
Not a fit: Patients who have not had a stroke or those with hemorrhagic strokes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and outcomes for stroke patients.
How similar studies have performed: While the role of NETs in other conditions has been studied, this specific approach to targeting NET formation in ischemic stroke is novel and has not been extensively tested.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAMPBELL, ROBERT A — WASHINGTON UNIVERSITY
- Study coordinator: CAMPBELL, ROBERT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.