How plant viruses affect gene expression and chromatin dynamics
Modulation of host chromatin dynamics and gene expression by viral biomolecular condensates
['FUNDING_R15'] · UNIVERSITY OF MISSOURI KANSAS CITY · NIH-10882241
This study is looking at how a specific plant virus affects the way plant cells work, especially how they manage their genes, and it's designed to help students learn about these exciting scientific techniques along the way.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI KANSAS CITY (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10882241 on ClinicalTrials.gov |
What this research studies
This research investigates how certain plant viruses, specifically the Pea enation mosaic virus 2, influence the behavior of chromatin and gene expression in host cells. By using advanced techniques like ATAC sequencing and RNA sequencing, the study aims to understand how a viral protein called p26 interacts with the nucleolus and alters chromatin structure. This could reveal mechanisms by which viruses manipulate host cellular processes, potentially leading to new insights in virology and gene regulation. The project also emphasizes training for undergraduate researchers in these methodologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the molecular mechanisms of viral infections and their effects on cellular functions.
Not a fit: Patients with conditions unrelated to viral infections or chromatin dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling viral infections by understanding how viruses manipulate host gene expression.
How similar studies have performed: While the specific approach of using plant viruses to study chromatin dynamics is relatively novel, similar methodologies have shown promise in other areas of virology and gene regulation.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF MISSOURI KANSAS CITY — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAY, JARED PAUL — UNIVERSITY OF MISSOURI KANSAS CITY
- Study coordinator: MAY, JARED PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.