How placental vesicles influence the mother's immune system during pregnancy
Placental extracellular vesicles as regulators of maternal adaptive immunity
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10652444
This study is looking at how tiny particles from the placenta help the mother's immune system accept the baby during pregnancy, which could lead to better understanding and care for moms and their little ones.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10652444 on ClinicalTrials.gov |
What this research studies
This research investigates how extracellular vesicles released from the placenta communicate with the mother's immune system to prevent rejection of the fetus. The study aims to understand the regulatory signals these vesicles send to maternal immune cells, which is crucial for maintaining a healthy pregnancy. By examining these interactions in vivo, the research seeks to uncover the mechanisms that allow the semi-allogeneic fetus to coexist with the mother's immune system without being attacked. This could lead to new insights into maternal-fetal health and immune responses during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those using donor oocytes or undergoing surrogate pregnancies.
Not a fit: Patients who are not pregnant or those with no history of immune-related pregnancy complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of pregnancy complications related to immune responses.
How similar studies have performed: While the concept of extracellular vesicles in immune regulation is gaining traction, this specific investigation into placental vesicles is relatively novel and has not been extensively tested.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORELLI, ADRIAN E. — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: MORELLI, ADRIAN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.