How placental cells respond to cytomegalovirus infection during pregnancy
Trophoblast development and placental susceptibility to cytomegalovirus infection
This study is looking at how a common virus called human cytomegalovirus (HCMV) impacts the placenta, which is important for a healthy pregnancy, by focusing on the cells that make up the placenta and help keep the baby safe from infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11092723 on NIH RePORTER |
What this research studies
This research investigates how human cytomegalovirus (HCMV) affects the placenta, which is crucial for fetal development. The study focuses on trophoblasts, the cells that form the placenta and protect against infections. By examining how these cells respond to HCMV, the researchers aim to understand the mechanisms that lead to adverse pregnancy outcomes. The approach includes using advanced techniques to analyze cell behavior and gene expression in response to the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those in their first trimester, who may be at risk for infections affecting the placenta.
Not a fit: Patients who are not pregnant or those who are beyond the first trimester may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing congenital infections and enhancing pregnancy outcomes.
How similar studies have performed: Previous research has shown promising results in understanding viral infections in placental cells, indicating that this approach has potential for significant findings.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Bierle, Craig John — University of Minnesota
- Study coordinator: Bierle, Craig John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.