How physical forces influence lung cell development and function
Official title: Biophysical force affects type 1 alveolar epithelial cell-mediated regulation of the pulmonary matrisome and lung development
Funded at Ut Southwestern Medical Center · NIH-10864087 · Data updated 2026-11-12
This study is looking at how certain physical forces affect lung cells that are important for breathing, especially in premature babies with bronchopulmonary dysplasia (BPD), to find better ways to help treat lung problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $155,196 |
| NIH project number | 1K08HL173564-01 |
| Project ID | NIH-10864087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants or children diagnosed with bronchopulmonary dysplasia.
✕Less likely to help
Patients with lung conditions unrelated to bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research investigates the impact of biophysical forces on type 1 alveolar epithelial cells, which play a crucial role in lung development and function. The study aims to understand how these forces regulate the pulmonary matrisome, a network of proteins that supports lung architecture, particularly in the context of bronchopulmonary dysplasia (BPD), a common condition in premature infants. The research will utilize advanced techniques in transcriptomics, epigenetics, and mechanobiology to explore these cellular processes. By focusing on the cellular mechanisms involved, the research seeks to uncover new insights that could lead to improved treatments for lung-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with bronchopulmonary dysplasia and other lung development issues.
How similar studies have gone: Previous research has shown promising results in understanding lung development and the role of cellular mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Callaway, Danielle Arden — Ut Southwestern Medical Center
- Study coordinator: Callaway, Danielle Arden
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.