How physical forces affect nerve repair and myelination
Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair
This study is looking at how physical forces affect special cells that help repair nerves, which could lead to better treatments for people with nerve injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10756095 on NIH RePORTER |
What this research studies
This research explores the role of mechanical stimuli in the differentiation and repair of Schwann cells, which are essential for the health of the peripheral nervous system. By examining how these cells respond to physical forces from their environment, the study aims to uncover the mechanisms that influence myelination and nerve regeneration after injury. The research will focus on specific proteins, YAP and TAZ, to understand their role in Schwann cell function and regeneration. Patients may benefit from insights that could lead to improved treatments for nerve injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with peripheral nerve injuries or conditions affecting nerve function.
Not a fit: Patients with central nervous system disorders or those without peripheral nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance nerve repair and recovery for patients with peripheral nerve injuries.
How similar studies have performed: While the field of mechanobiology is emerging, similar approaches have shown promise in understanding cell behavior and regeneration, suggesting potential for success in this area.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Poitelon, Yannick — Albany Medical College
- Study coordinator: Poitelon, Yannick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.