How physical activity, sleep, and genetics affect heart health
Official title: Impact of Physical Activity, Sleep, and Genetic Background on Cardiovascular Risk in the All of Us Program
Funded at Vanderbilt University Medical Center · NIH-10929498 · Data updated 2026-11-12
This study is looking at how your exercise habits, sleep quality, and genes work together to affect your heart health, and it's for anyone interested in finding out how to improve their cardiovascular health based on their unique background.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $262,500 |
| NIH project number | 5R21HL172038-02 |
| Project ID | NIH-10929498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are interested in understanding how their physical activity and sleep habits, combined with their genetic background, affect their heart health.
✕Less likely to help
Patients who have no interest in lifestyle changes or those with pre-existing severe cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the relationship between physical activity, sleep patterns, and genetic factors in influencing cardiovascular risk. By utilizing data from the All of Us Research Program, which includes wearable device information and whole-genome sequencing, the study aims to understand how these modifiable behaviors interact with genetic predispositions. Participants will provide data on their activity levels and sleep quality, which will be analyzed to determine their impact on heart health outcomes. The goal is to identify personalized recommendations for improving cardiovascular health based on individual genetic backgrounds.
Why it matters
Potential benefit: If successful, this research could lead to tailored lifestyle recommendations that significantly reduce cardiovascular risk for individuals based on their genetic makeup.
How similar studies have gone: Previous research has shown promising results in understanding the interplay between lifestyle factors and genetics in various health outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Brittain, Evan L — Vanderbilt University Medical Center
- Study coordinator: Brittain, Evan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.