How phthalates affect ovulation and fertility in women
Phthalate-Induced Dysregulation of Prostaglandin and Angiogenic Function During Ovulation in Women
This study is looking at how certain chemicals called phthalates, which are found in many everyday products, might affect women's ovulation and fertility, and it aims to find ways to help counteract any negative effects these chemicals may have.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10973604 on NIH RePORTER |
What this research studies
This research investigates how phthalates, chemicals found in many everyday products, disrupt the normal processes of ovulation and fertility in women. It focuses on understanding the mechanisms by which these chemicals interfere with prostaglandin and angiogenic functions during ovulation. The study will also explore potential rescue strategies to counteract the negative effects of phthalates on ovulation, which is crucial for reproductive health. By examining both human and animal models, the research aims to provide insights into the impact of phthalate exposure on female fertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing difficulties with ovulation or infertility, particularly those who have been exposed to phthalates.
Not a fit: Patients who are not affected by ovulatory dysfunction or those who have other underlying causes of infertility unrelated to environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing fertility in women affected by phthalate exposure.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated that endocrine disruptors can significantly impact reproductive health, suggesting a potential for meaningful findings.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Hannon, Patrick Ryan — University of Kentucky
- Study coordinator: Hannon, Patrick Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.