How phospholipids affect fat and sugar balance in the liver
Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLD
This study is looking at how certain fats in our cells can affect how our bodies handle sugar and fat, especially for people with non-alcoholic fatty liver disease, to find new ways to help those struggling with insulin resistance and obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10816990 on NIH RePORTER |
What this research studies
This research investigates the role of membrane phospholipids in regulating fat and sugar metabolism, particularly in the context of non-alcoholic fatty liver disease (NAFLD). It aims to uncover the molecular mechanisms by which specific phospholipids influence metabolic control in skeletal muscle, potentially leading to new treatment options for patients with insulin resistance and obesity. The study will involve laboratory experiments to analyze how these phospholipids interact with proteins that regulate metabolism, providing insights into their role in liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with non-alcoholic fatty liver disease, particularly those experiencing insulin resistance or obesity.
Not a fit: Patients without metabolic disorders or those who do not have non-alcoholic fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing non-alcoholic fatty liver disease and improving metabolic health.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism, but this specific approach focusing on phospholipids in NAFLD is relatively novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cohen, David E. — Brigham and Women's Hospital
- Study coordinator: Cohen, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.