How phosphate levels affect kidney disease progression
Impact of Phosphaturia on Renal Osteopontin Production and PKD Progression
This study is looking at how phosphate levels in the kidneys might affect the worsening of autosomal dominant polycystic kidney disease (ADPKD), with the hope of finding ways to help patients manage their condition better through diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10894862 on NIH RePORTER |
What this research studies
This research investigates the role of phosphate excretion in the progression of autosomal dominant polycystic kidney disease (ADPKD). It focuses on how high levels of phosphate in the kidneys may lead to kidney injury and worsen the disease. By studying the mechanisms behind phosphate balance and its effects on kidney function, the research aims to identify potential therapeutic targets. Patients with ADPKD may benefit from insights gained regarding dietary phosphate and its impact on their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing the progression of kidney disease in patients with ADPKD.
How similar studies have performed: Previous research has indicated that dietary phosphate management can influence kidney function, suggesting that this approach may yield valuable insights.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Stubbs, Jason — University of Kansas Medical Center
- Study coordinator: Stubbs, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.