How pH changes affect gene regulation in neural crest development
Regulation of transcription factor activity in neural crest development by pH dynamics
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10656499
This study is looking at how changes in acidity levels can affect the way certain proteins interact with DNA during the development of important cells that help shape our faces and bodies, which could help us understand some birth defects better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10656499 on ClinicalTrials.gov |
What this research studies
This research investigates the role of pH dynamics in regulating how transcription factors bind to DNA during the development of neural crest cells, which are crucial for forming various structures in the body. By focusing on specific transcription factors known to influence craniofacial development, the study aims to understand how changes in pH can affect gene expression and cellular behavior. The researchers will conduct experiments to observe how these factors interact with DNA under different pH conditions, potentially revealing new insights into congenital abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or birth defects linked to neural crest development.
Not a fit: Patients with conditions unrelated to neural crest development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating birth defects related to neural crest development.
How similar studies have performed: While the specific approach of examining pH dynamics in transcription factor activity is novel, related research has shown that understanding gene regulation can lead to significant advancements in treating congenital defects.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARBER, DIANE L — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: BARBER, DIANE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.