How pesticides may cause inflammation and Parkinson's disease in older mice.
Mechanisms of pesticide-induced neuroinflammation and parkinsonism in aging mice.
This study looks at how being around pesticides might cause inflammation in the brain and lead to Parkinson's disease, using aging mice to help understand how these toxins affect our cells, with the hope of finding new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10993664 on NIH RePORTER |
What this research studies
This research investigates how exposure to pesticides can lead to neuroinflammation and the development of Parkinson's disease in aging mice. By studying the effects of environmental toxins on cellular stress and inflammation, the researchers aim to understand the role of inflammasomes—protein complexes that trigger inflammation—in neurodegenerative diseases. The study involves both animal models and comparisons with human patients to identify common mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have been exposed to pesticides or other environmental toxins and are experiencing symptoms of neurodegeneration.
Not a fit: Patients who do not have a history of pesticide exposure or are not experiencing neurodegenerative symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Parkinson's disease and other neurodegenerative conditions linked to environmental toxins.
How similar studies have performed: Previous research has shown success in understanding the role of inflammasomes in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Havrda, Matthew Charles — Dartmouth College
- Study coordinator: Havrda, Matthew Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.