How pesticide exposure and gut bacteria affect Parkinson's disease
Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related Pathologies
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10992141
This study is looking at how being exposed to pesticides might change the bacteria in our gut and how that could be linked to developing Parkinson's disease, especially since gut problems often happen before other symptoms show up. Researchers will use animal models to see how pesticides affect both the brain and the gut, hoping to learn more about how these changes could influence the progression of Parkinson's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10992141 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between pesticide exposure and changes in the gut microbiome, and how these factors may contribute to the development of Parkinson's disease (PD). The study focuses on understanding how gastrointestinal dysfunctions, which often occur before PD symptoms, may signal the onset of neurological issues. By using animal models, researchers will explore the effects of pesticides on both the central nervous system and the gastrointestinal tract, aiming to uncover the physiological impacts of microbiome alterations on PD progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Parkinson's disease or those experiencing early gastrointestinal symptoms associated with PD.
Not a fit: Patients who have a confirmed genetic cause of Parkinson's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating Parkinson's disease by targeting gut health and pesticide exposure.
How similar studies have performed: Previous research has shown promising results in understanding the role of the microbiome in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAMPSON, TIMOTHY ROBERT — EMORY UNIVERSITY
- Study coordinator: SAMPSON, TIMOTHY ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.