How PDE4 affects alcohol tolerance and drinking behavior
PDE4 regulation of GABA-A receptors in alcohol tolerance and consumption
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-10880441
This study is looking at how a certain enzyme affects brain receptors that help control alcohol use, with the hope that blocking this enzyme could lead to new ways to help people who struggle with drinking too much.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-10880441 on ClinicalTrials.gov |
What this research studies
This research investigates the role of phosphodiesterase 4 (PDE4) in regulating GABA-A receptors, which are important for understanding alcohol tolerance and consumption. The study aims to explore how inhibiting PDE4 can reduce alcohol drinking behaviors by enhancing the function of GABA-A receptors in the brain. By examining the effects of PDE4 inhibitors on alcohol tolerance and consumption in animal models, the research seeks to uncover potential mechanisms that could lead to new treatments for alcohol use disorder. Patients may benefit from insights gained about how their bodies respond to alcohol and potential new therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who struggle with alcohol consumption or have a history of alcohol use disorder.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help reduce alcohol consumption and prevent alcohol use disorder.
How similar studies have performed: Previous research has shown that PDE4 inhibitors can effectively reduce alcohol consumption in animal models, suggesting a promising avenue for further exploration.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MESSING, ROBERT O. — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: MESSING, ROBERT O.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.