How past flu immunity changes airborne spread of flu
Role of preexisting immunity on airborne transmission of influenza viruses
This project looks at whether immunity from past flu infections or vaccines changes how likely flu is to spread through the air to people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11261519 on NIH RePORTER |
What this research studies
This project uses laboratory experiments and animal models to understand how immune memory from prior flu infection or vaccination affects airborne transmission. Researchers will use ferret models and detailed immune testing to identify which immune responses reduce the chance of catching flu through the air. They will examine how gradual changes in circulating flu strains (antigenic drift) affect transmission risk and compare different vaccine platforms to see how they alter that risk. Findings are intended to link lab and animal results to what might protect people and guide improved vaccines or public health measures.
Who could benefit from this research
Good fit: People with a history of prior influenza infection or recent influenza vaccination, or those willing to donate blood or other samples for research, would be most relevant for related human studies.
Not a fit: People without prior flu exposure who are not willing to provide samples or take part in vaccine-related studies are unlikely to directly benefit from this grant.
Why it matters
Potential benefit: If successful, this work could help improve vaccines and public health strategies that reduce airborne spread of seasonal and pandemic influenza.
How similar studies have performed: Previous animal studies, including ferret experiments, have shown that prior infection can block airborne transmission between animals, but translating those findings to people is still being explored.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Lakdawala, Seema S. — Emory University
- Study coordinator: Lakdawala, Seema S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.