How parts of the kidney respond to low oxygen
A systems biology approach to identify cortical and medullary gene regulatory networks related to Hypoxia Inducible Factor-1A
This project maps how low-oxygen response genes act in different parts of the kidney to help people who have acute kidney injury.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11251812 on NIH RePORTER |
What this research studies
Researchers will analyze existing multiome data and new kidney tissue samples to see which gene 'switches' are active in the kidney cortex versus the medulla. They will look for open DNA regions where the low-oxygen regulator HIF1A and partnering transcription factors bind. By building gene regulatory networks for cortex and medulla cells, the team aims to show how cells change under low-oxygen stress. They will relate those cell states to known links with worse long-term outcomes.
Who could benefit from this research
Good fit: Ideal candidates are people with acute kidney injury (or with available kidney biopsy tissue) who can provide or consent to use kidney biopsy samples, including samples contributed to the Kidney Precision Medicine Project.
Not a fit: Patients without acute kidney injury or those who cannot or will not provide biopsy tissue are unlikely to receive direct benefit from participating in this tissue-focused research.
Why it matters
Potential benefit: If successful, this work could point to new targets to protect kidney cells from low-oxygen damage and guide future treatments for acute kidney injury.
How similar studies have performed: HIF1A and cell-type gene patterns have been studied before and multiome approaches have identified cell-specific signals, but mapping cortex-versus-medulla HIF1A-related regulatory networks is a newer approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Schaub, Jennifer Ann — University of Michigan at Ann Arbor
- Study coordinator: Schaub, Jennifer Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.