How papillomavirus proteins affect basal epithelial cells
Official title: Establishment of basal epithelial identity by papillomavirus oncoproteins
Funded at Tufts University Boston · NIH-11190514 · Data updated 2026-11-12
This study is looking at how certain proteins from high-risk HPV can change the behavior of skin cells, which might help us understand why these infections can sometimes lead to cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $200,063 |
| NIH project number | 7R21AI176035-02 |
| Project ID | NIH-11190514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with HPV infections, particularly those at risk for developing HPV-related cancers.
✕Less likely to help
Patients who do not have HPV infections or those with non-epithelial cancers may not benefit from this research.
What this research studies
This research investigates how specific proteins from high-risk human papillomaviruses (HPVs) influence the behavior of basal epithelial cells, which are crucial for maintaining the integrity of skin and mucosal tissues. The study aims to understand the mechanisms by which these viral proteins, particularly E6 and E7, help cells remain in the basal layer of the epithelium, potentially leading to cancer. Using advanced three-dimensional tissue models, researchers will track cell migration and assess how these proteins affect cell differentiation and signaling pathways. This could provide insights into the persistent infections caused by HPVs and their role in cancer development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HPV-related cancers by targeting the mechanisms that allow the virus to persist in epithelial tissues.
How similar studies have gone: Previous research has shown that understanding viral mechanisms in cell behavior can lead to significant advancements in cancer prevention and treatment, indicating a promising avenue for this study.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: White, Elizabeth a — Tufts University Boston
- Study coordinator: White, Elizabeth a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.