How papillomavirus proteins affect basal epithelial cells
Establishment of basal epithelial identity by papillomavirus oncoproteins
['FUNDING_R21'] · TUFTS UNIVERSITY BOSTON · NIH-11190514
This study is looking at how certain proteins from high-risk HPV can change the behavior of skin cells, which might help us understand why these infections can sometimes lead to cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11190514 on ClinicalTrials.gov |
What this research studies
This research investigates how specific proteins from high-risk human papillomaviruses (HPVs) influence the behavior of basal epithelial cells, which are crucial for maintaining the integrity of skin and mucosal tissues. The study aims to understand the mechanisms by which these viral proteins, particularly E6 and E7, help cells remain in the basal layer of the epithelium, potentially leading to cancer. Using advanced three-dimensional tissue models, researchers will track cell migration and assess how these proteins affect cell differentiation and signaling pathways. This could provide insights into the persistent infections caused by HPVs and their role in cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with HPV infections, particularly those at risk for developing HPV-related cancers.
Not a fit: Patients who do not have HPV infections or those with non-epithelial cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing HPV-related cancers by targeting the mechanisms that allow the virus to persist in epithelial tissues.
How similar studies have performed: Previous research has shown that understanding viral mechanisms in cell behavior can lead to significant advancements in cancer prevention and treatment, indicating a promising avenue for this study.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, ELIZABETH A — TUFTS UNIVERSITY BOSTON
- Study coordinator: WHITE, ELIZABETH A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.