How p53 helps control cancer by regulating metabolism
p53-mediated metabolic regulation in tumor suppression
['FUNDING_OTHER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10898749
This study is looking at how a protein called p53 can help stop cancer by managing how cells use energy, and it hopes to find new ways to treat cancer that take advantage of p53's ability to fight tumors while keeping healthy cells safe.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10898749 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the p53 protein in preventing cancer by regulating various cellular processes, particularly focusing on its metabolic functions. The study aims to understand how activating p53 can suppress tumor growth while minimizing damage to normal tissues. By exploring the unique metabolic vulnerabilities of cancer cells, the research seeks to develop targeted therapies that leverage these weaknesses. Patients may benefit from new treatment strategies that effectively utilize p53's tumor-suppressing abilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that involve p53 inactivation.
Not a fit: Patients with cancers that do not involve p53 or those with advanced-stage cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative cancer therapies that effectively target tumors while sparing healthy cells.
How similar studies have performed: Previous research has shown promising results in targeting metabolic vulnerabilities in cancer cells, indicating potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GU, WEI — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: GU, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment, Cancers