How ozone affects ragweed pollen and asthma symptoms
Official title: Pulmonary Response to Ozone-exposed Ragweed Pollen Grains
Funded at Mayo Clinic Arizona · NIH-11115726 · Data updated 2026-11-12
This study is looking at how ozone pollution affects ragweed pollen, which can make asthma symptoms worse, to help us understand why air pollution might lead to more asthma problems for people who are allergic to ragweed.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | June 13, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $196,080 |
| NIH project number | 5R21AI182888-02 |
| Project ID | NIH-11115726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with allergic asthma, particularly those who are sensitive to ragweed pollen.
✕Less likely to help
Patients without asthma or those who are not allergic to ragweed pollen may not benefit from this research.
What this research studies
This research investigates the impact of ozone exposure on ragweed pollen, a major allergen for people with asthma. The study aims to understand how ozone alters the structure and chemical composition of ragweed pollen, potentially worsening asthma symptoms. Researchers will use advanced imaging techniques and in vivo models to observe the biological responses triggered by these changes, focusing on inflammation in the airways. By examining these interactions, the research seeks to uncover the mechanisms behind increased asthma morbidity linked to air pollution.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of asthma exacerbations caused by environmental factors.
How similar studies have gone: Previous research has shown that environmental factors like air pollution can significantly impact asthma, suggesting that this study's focus on ozone and ragweed pollen is both relevant and necessary.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Jacobsen, Elizabeth a — Mayo Clinic Arizona
- Study coordinator: Jacobsen, Elizabeth a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.