How oxycodone affects brain circuits during withdrawal
DAT-Regulation of Nucleus Accumbens Microcircuitry by Oxycodone Exposure and Withdrawal
This study is looking at how using and then stopping oxycodone affects certain brain areas that control feelings of discomfort, with the goal of finding better ways to help people manage withdrawal symptoms and reduce their dependence on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10671656 on NIH RePORTER |
What this research studies
This research investigates the effects of oxycodone exposure and withdrawal on specific brain circuits involved in aversive behavior. By focusing on the nucleus accumbens, a brain region linked to both reward and aversion, the study aims to understand how certain neurons respond during withdrawal. The researchers will analyze the activity of fast-spiking interneurons and medium spiny neurons to uncover changes that occur during oxycodone withdrawal. This knowledge could lead to better strategies for managing withdrawal symptoms and reducing opioid dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing withdrawal symptoms from oxycodone or other prescription opioids.
Not a fit: Patients who are not currently using opioids or are not experiencing withdrawal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for opioid withdrawal, helping patients manage their symptoms more effectively.
How similar studies have performed: Previous research has shown promising results in understanding the neural circuits involved in opioid withdrawal, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Rothwell, Patrick — University of Minnesota
- Study coordinator: Rothwell, Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.