How oxidative stress affects RNA methylation and gene expression
Oxidative stress and RNA methylation
This study is looking at how things like pollution and smoking can affect a specific chemical change in our RNA that helps control gene activity, which might be linked to health issues like obesity, autoimmune diseases, and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10770467 on NIH RePORTER |
What this research studies
This research investigates the role of oxidative stress in regulating RNA methylation, specifically focusing on the chemical modification known as N6-methyladenosine (m6A). The study aims to understand how environmental factors that cause oxidative stress, such as pollution and smoking, may influence the activity of RNA methyltransferases and demethylases, which are crucial for gene expression. By exploring the connection between oxidative stress and RNA methylation, the research seeks to uncover potential mechanisms that could link these processes to various diseases, including obesity, autoimmunity, and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by conditions associated with oxidative stress, such as obesity, autoimmune disorders, or certain cancers.
Not a fit: Patients who do not have conditions related to oxidative stress or RNA methylation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to misregulated RNA methylation.
How similar studies have performed: Other research has shown promising results in understanding the relationship between oxidative stress and gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Aguiar, Ricardo C — University of Texas Hlth Science Center
- Study coordinator: Aguiar, Ricardo C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.