How oxidative stress affects blood flow and thinking in the brain
sGC oxidative stress controls cerebral blood flow and cognitive function
This study is looking at how stress in the body affects blood flow to the brain and thinking skills in people with age-related dementia, like Alzheimer's, to find new ways to help improve their memory and cognitive function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10373741 on NIH RePORTER |
What this research studies
This research investigates the role of oxidative stress in regulating cerebral blood flow and cognitive function, particularly in the context of age-related dementia such as Alzheimer's disease. The study focuses on the nitric oxide signaling pathway and its receptor, soluble Guanylyl Cyclase (sGC), which are crucial for maintaining healthy blood flow to the brain. By understanding how oxidative stress impacts these mechanisms, the research aims to identify potential therapeutic targets for improving cognitive function in affected individuals. Patients may be involved in assessments that explore these biological processes and their relationship to cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients with non-age-related cognitive impairments or those without any signs of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and cognitive function in patients with Alzheimer's disease and other forms of dementia.
How similar studies have performed: Previous research has shown promising results in targeting nitric oxide signaling pathways for cognitive improvement, suggesting that this approach may be effective.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Sharina, Iraida G. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Sharina, Iraida G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.