How outdoor air pollution affects asthma in children
Chronic outdoor air pollution, airway epithelial "omics" and asthma exacerbations in children
This study is looking at how long-term outdoor air pollution affects asthma in kids aged 0-11, and it hopes to find signs that can help us understand which children might have more trouble with their asthma because of pollution, so we can create better treatments for them.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10873313 on NIH RePORTER |
What this research studies
This research investigates the impact of chronic outdoor air pollution on asthma exacerbations in children aged 0-11 years. It aims to identify biomarkers that can predict which children are most susceptible to worsening asthma due to air pollution. By studying the airway epithelium, the research will explore how pollutants affect gene expression and DNA methylation in these children. The ultimate goal is to improve asthma care by developing targeted interventions for those at highest risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with asthma and are exposed to outdoor air pollution.
Not a fit: Patients who do not have asthma or are not exposed to significant levels of outdoor air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for children with asthma, reducing the frequency of exacerbations and improving their quality of life.
How similar studies have performed: Previous research has shown that understanding the effects of environmental factors like air pollution on asthma can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Rosser, Franziska — University of Pittsburgh at Pittsburgh
- Study coordinator: Rosser, Franziska
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.