How Our DNA Folds to Control Gene Activity
Fine-Scale Genome Folding Relative to Transcription and Location
This research explores how the intricate folding of our DNA within cells influences which genes are active, helping us understand fundamental processes of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11112314 on NIH RePORTER |
What this research studies
This research dives deep into how the human genome, our complete set of DNA, is carefully folded within the cell's nucleus. We know that this folding creates specific structures, like tiny loops, that are crucial for how our genes work. This project aims to uncover how these detailed folding patterns change as genes are being used, and how their position inside the cell nucleus also plays a role. By understanding these basic mechanisms, we hope to learn more about how our bodies function at the most fundamental level.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation or recruitment at this stage.
Not a fit: Patients seeking immediate clinical treatment or direct therapeutic interventions would not benefit from this basic science project.
Why it matters
Potential benefit: Understanding how DNA folding impacts gene activity could eventually lead to new insights into diseases caused by gene regulation problems.
How similar studies have performed: While the specific high-resolution investigations into sub-genic discordant compartments are novel, the broader field of genome organization and its link to gene transcription has seen significant advancements.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Rowley, Michael Jordan — University of Nebraska Medical Center
- Study coordinator: Rowley, Michael Jordan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.