How our brains create emotions

Spatiotemporal dynamics of the human emotion network

NIH-funded research University of California, San Francisco · NIH-11123099

This project aims to understand how brain networks work when we experience emotions and how problems in these networks contribute to conditions like depression and anxiety.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Francisco NIH-funded
Lab location1 site (San Francisco, United States)
Project IDNIH-11123099 on NIH RePORTER

What this research studies

We want to learn how different parts of the brain work together to create our feelings and how this process might go wrong in people with emotional challenges. By using special brain recordings called iEEG, we can see brain activity in great detail, down to milliseconds, which helps us map out the brain's emotion network. This detailed view will help us connect specific brain patterns to how we feel, behave, and even how our bodies react to emotions. Ultimately, we hope to find unique brain signals that can help us better understand and treat conditions like depression and anxiety.

Who could benefit from this research

Good fit: This research is for adults aged 21 and older who are experiencing affective symptoms and may be undergoing intracranial electroencephalography (iEEG) for clinical reasons.

Not a fit: Individuals who do not have neuropsychiatric disorders or are not candidates for iEEG monitoring would not directly benefit from participating in this specific research.

Why it matters

Potential benefit: If successful, this work could lead to new ways to identify and treat emotional symptoms in neuropsychiatric disorders by understanding their specific brain patterns.

How similar studies have performed: While functional neuroimaging has explored emotion networks, this project uses advanced iEEG to capture brain activity at a much finer spatiotemporal resolution, offering a novel approach to understanding unique neural signatures of emotions.

Where this research is happening

San Francisco, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.