How our body clock and diet affect health
Official title: Circadian Clock and Dietary Restriction
Funded at Cleveland State University · NIH-11115718 · Data updated 2026-11-12
This project explores how our body's internal clock and calorie intake work together to influence healthy aging and protect against diseases like cancer and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 15, 2011 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $473,578 |
| NIH project number | 5R01AG039547-14 |
| Project ID | NIH-11115718 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not involve direct patient participation at this stage, but future applications could benefit individuals interested in healthy aging, metabolic health, or prevention of age-related diseases.
✕Less likely to help
Patients seeking immediate treatment options or direct clinical interventions would not find direct benefit from this basic science project.
What this research studies
We know that diet is a major factor in our health, and limiting calories can improve metabolism, slow aging, and reduce the risk of many age-related conditions. This work aims to understand how calorie restriction affects a key pathway in our cells, called mTOR, and how this process is connected to our daily rhythms. By studying these connections, we hope to learn more about how diet helps our bodies adapt and stay healthy as we get older. We are using advanced laboratory methods to compare the effects of calorie restriction, normal eating, and fasting on these cellular signals.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve metabolism, slow aging, and prevent age-related diseases by understanding the interplay between diet and our body's internal clock.
How similar studies have gone: The roles of calorie restriction and circadian rhythms in health are well-established areas of research, and this project builds upon existing knowledge by exploring their specific crosstalk.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Kondratov, Roman V — Cleveland State University
- Study coordinator: Kondratov, Roman V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.