How our body clock affects inflammation and immune responses
Complement and Circadian Interactions in Inflammation and Immunity
This study is looking at how changes in our body's natural clock can affect inflammation and lead to health problems like cancer and diabetes, and it aims to find new ways to help people who are struggling with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11067853 on NIH RePORTER |
What this research studies
This research investigates the relationship between our biological clock and inflammation, particularly how disruptions in circadian rhythms can lead to various health issues such as cancer, diabetes, and inflammatory bowel disease. The study focuses on the role of complement anaphylatoxins, which are molecules involved in immune responses, and how they may connect circadian disruption to disease vulnerability. By understanding these mechanisms, the research aims to identify potential therapeutic targets for improving health outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing chronic health issues related to inflammation, such as those with inflammatory bowel disease, asthma, or metabolic disorders.
Not a fit: Patients who do not have any chronic inflammatory conditions or circadian rhythm disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases linked to circadian disruption.
How similar studies have performed: Previous studies have shown promising results in understanding the links between circadian rhythms and various diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mahan, Kristin Eckel — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mahan, Kristin Eckel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.