How Our Bodies Create Diverse Antibodies
Mechanisms That Control Antigen Receptor Variable Region Exon Assembly
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11086162
This research explores the fundamental ways our immune cells, called B cells, create a wide variety of antibodies to fight off infections and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11086162 on ClinicalTrials.gov |
What this research studies
Our immune system relies on B cells to produce antibodies that protect us from illness. This project looks closely at how B cells assemble the genetic pieces needed to make these diverse antibodies, a process called V(D)J recombination. Researchers are particularly interested in understanding how different parts of the antibody genes are brought together in a precise way. By studying these basic steps, we can learn more about how our immune system works and what happens when it doesn't function correctly.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but its findings are relevant to anyone affected by immune system disorders.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a clinical trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a deeper understanding of immune system function, which is essential for developing new treatments for immune deficiencies, autoimmune diseases, and cancers.
How similar studies have performed: This research builds upon previous discoveries by the team, including new technologies developed during the current funding period, suggesting a strong foundation for the proposed work.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALT, FREDERICK W. — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: ALT, FREDERICK W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.