How our ancestors' experiences affect gene expression and lifespan in worms
Linking transgenerational epigenetic inheritance to gene expression and lifespan in C. elegans
['FUNDING_R15'] · UNIVERSITY OF MASSACHUSETTS LOWELL · NIH-10358927
This study looks at how the experiences of one generation can affect the health and traits of the next generation, using tiny worms to see how changes in their DNA packaging can influence their biology and health over time.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS LOWELL (nih funded) |
| Locations | 1 site (LOWELL, UNITED STATES) |
| Trial ID | NIH-10358927 on ClinicalTrials.gov |
What this research studies
This research investigates how the experiences of previous generations can influence the health and biology of their descendants, using the model organism Caenorhabditis elegans (a type of worm). By studying the molecular changes that occur in these worms over many generations, the researchers aim to understand how specific modifications to the proteins that package DNA can affect gene expression and overall physiology. The study focuses on the role of epigenetic changes, particularly those involving histone modifications, in shaping the traits passed down through generations. This work could provide insights into the biological mechanisms behind inherited traits and health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with a family history of health conditions that may be influenced by epigenetic factors.
Not a fit: Patients who do not have a family history of conditions related to epigenetic inheritance may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how inherited experiences affect health, potentially informing treatments for conditions influenced by genetics and environment.
How similar studies have performed: Other research has shown promising results in understanding transgenerational epigenetic inheritance, but this specific approach using C. elegans is relatively novel.
Where this research is happening
LOWELL, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS LOWELL — LOWELL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, TERESA WEI-SY — UNIVERSITY OF MASSACHUSETTS LOWELL
- Study coordinator: LEE, TERESA WEI-SY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.