How organs talk to each other through hormones and proteins
Integrative approaches to dissection of endocrine communication
This project maps the protein signals that organs send and receive in people with adult-onset (type 2) diabetes to find communication pathways that affect disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11369488 on NIH RePORTER |
What this research studies
From your point of view, researchers are looking at blood proteins and gene activity from different tissues to see how organs communicate. They combine large public human datasets with new proteomic measurements and a computer pipeline that ranks likely signaling proteins. Promising signals are then tested in the lab to learn which tissues they act on and what they do. The goal is to connect population data to experiments so discoveries could eventually point to new ways to treat diabetes or its complications.
Who could benefit from this research
Good fit: People with adult-onset (type 2) diabetes who can provide blood or tissue samples or share health data would be the most relevant participants for this work.
Not a fit: Patients seeking immediate personal treatment changes are unlikely to get direct benefit because this is discovery-focused research rather than a therapy trial.
Why it matters
Potential benefit: If successful, this work could identify new signaling molecules or pathways that become targets for therapies to better control blood sugar or prevent complications of type 2 diabetes.
How similar studies have performed: Related proteomics and bioinformatics efforts have already identified some inter-organ signals and a subset have been experimentally validated, though much of this area remains novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Seldin, Marcus Michael — University of California-Irvine
- Study coordinator: Seldin, Marcus Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.