How organ donor body clocks affect transplant acceptance
Official title: Organ donor circadian clocks in transplantation acceptance
Funded at Washington University · NIH-11048610 · Data updated 2026-11-12
This study is looking at how our body's natural clocks affect organ transplants, aiming to find ways to help transplanted organs work better by understanding the timing of immune responses in both donors and recipients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 16, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $705,421 |
| NIH project number | 1R01HL173976-01A1 |
| Project ID | NIH-11048610 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals awaiting organ transplants, particularly those who may benefit from enhanced understanding of transplant timing and donor characteristics.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with conditions unrelated to organ acceptance may not benefit from this research.
What this research studies
This research investigates the role of circadian rhythms, or biological clocks, in organ transplantation. It focuses on how these rhythms in both organ donors and recipients can influence the acceptance of transplanted organs. By studying the timing of immune responses and cellular defenses during transplantation, the research aims to uncover mechanisms that could improve transplant outcomes. The approach includes analyzing biological markers and rhythms in organ donors to understand their impact on graft function.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for organ transplantation, enhancing the acceptance and longevity of transplanted organs.
How similar studies have gone: While the concept of circadian rhythms in transplantation is emerging, this specific approach to studying donor and recipient clocks is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Haspel, Jeffrey Adam — Washington University
- Study coordinator: Haspel, Jeffrey Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.