How oral bacteria may influence colon cancer development
Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
This study is looking at how a common mouth bacterium called Parvimonas micra might play a role in the development of colorectal cancer, and it’s for anyone interested in understanding how oral health could impact cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10918124 on NIH RePORTER |
What this research studies
This research investigates the role of the oral bacterium Parvimonas micra in the development of colorectal cancer (CRC). It aims to understand how this bacterium, commonly found in healthy mouths, can contribute to cancer by altering DNA methylation in the colon and blood of patients. The study will utilize mouse models to explore the mechanisms by which P. micra affects cancer progression and the potential for these changes to predict CRC risk. By examining the interactions between oral microbes and colon cancer, the research seeks to uncover new insights into cancer biology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal cancer or those at high risk for developing the disease.
Not a fit: Patients who do not have colorectal cancer or are not at risk for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal cancer by targeting the microbial influences on cancer development.
How similar studies have performed: Other research has shown promising results in understanding the role of gut microbiota in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Khazaie, Khashayarsha — Mayo Clinic Arizona
- Study coordinator: Khazaie, Khashayarsha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.