How oral bacteria affect immune response in gum disease
The role of oral spirochete virulence factors in the impairment of neutrophil response
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-10454359
This study looks at how certain bacteria in your mouth can affect your immune system and contribute to gum disease, with the hope of finding better treatments for people dealing with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-10454359 on ClinicalTrials.gov |
What this research studies
This research investigates how certain bacteria in the mouth, specifically oral spirochetes, impact the immune response related to gum disease. It focuses on a protein produced by these bacteria that can impair the function of neutrophils, which are crucial immune cells that help fight infections. By studying the interactions between these bacteria and immune cells, the research aims to uncover new insights into the mechanisms of periodontal disease and identify potential therapeutic targets. Patients with gum disease may benefit from findings that could lead to improved treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal disease or those with high levels of oral spirochetes.
Not a fit: Patients without periodontal disease or those not affected by oral spirochetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response in patients with periodontal disease.
How similar studies have performed: Previous research has shown that understanding bacterial interactions with the immune system can lead to significant advancements in treating infections, suggesting this approach has potential.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VISSER, MICHELLE B — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: VISSER, MICHELLE B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.