How oral bacteria affect blood vessel health
Role of Oral Microbiota on Vascular Function
['FUNDING_OTHER'] · MEHARRY MEDICAL COLLEGE · NIH-10918050
This study is looking at how gum disease might affect blood vessel health in people with diabetes, focusing on how infections in the mouth can lead to problems with blood flow and heart health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEHARRY MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10918050 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between oral health, specifically periodontal diseases, and vascular function in individuals with diabetes. It explores how chronic periodontal infections can lead to reduced nitric oxide levels, which are crucial for maintaining healthy blood vessels. By studying the inflammatory responses and oxidative stress caused by oral bacteria, the research aims to understand the mechanisms that contribute to cardiovascular complications in diabetic patients. The approach includes both human cell studies and animal models to assess the impact of oral microbiota on vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who also suffer from periodontal disease.
Not a fit: Patients without diabetes or periodontal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular diseases in diabetic patients by addressing oral health.
How similar studies have performed: Previous studies have shown a significant link between periodontal disease and cardiovascular health, suggesting that this research builds on established findings.
Where this research is happening
NASHVILLE, UNITED STATES
- MEHARRY MEDICAL COLLEGE — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GANGULA, PANDU R — MEHARRY MEDICAL COLLEGE
- Study coordinator: GANGULA, PANDU R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus