How optic nerve cells respond to mechanical strain and fibrosis
Official title: Optic nerve head cellular interactions in response to mechanical strain and fibrosis
Funded at Upstate Medical University · NIH-11080321 · Data updated 2026-11-12
This study is looking at how certain cells in the eye's optic nerve respond to stress and changes that happen in glaucoma, using a special 3D setup to better understand their interactions, which could help find new ways to treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $195,733 |
| NIH project number | 5R21EY036198-02 |
| Project ID | NIH-11080321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for glaucoma or those experiencing early signs of the disease.
✕Less likely to help
Patients with advanced glaucoma or those who have already lost significant vision may not benefit from this research.
What this research studies
This research investigates the interactions between cells in the optic nerve head when subjected to mechanical strain and fibrosis, which are critical factors in glaucoma. By creating a 3D culture system that mimics the natural environment of these cells, researchers aim to understand how optic nerve head astrocytes and lamina cribrosa cells communicate and respond to stress. The study will focus on specific signaling pathways that may lead to fibrosis, particularly the role of a protein called fibronectin and its interaction with Toll-Like Receptor 4. This innovative approach could provide insights into the cellular mechanisms underlying glaucoma and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vision loss in glaucoma patients.
How similar studies have gone: While the specific approach of using a 3D culture system is innovative, previous studies have shown that understanding cellular interactions in similar contexts can lead to significant advancements in treatment.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Ganapathy, Preethi — Upstate Medical University
- Study coordinator: Ganapathy, Preethi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.