How opioids affect breathing control in the brainstem
Influence of Opioids on the Brainstem Respiratory Network
This study looks at how opioids affect the brain's breathing control system, especially in older adults, to help us understand why these medications can sometimes make it harder to breathe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10758551 on NIH RePORTER |
What this research studies
This research investigates how opioids influence the brainstem's respiratory network, which is crucial for controlling breathing. By examining the interactions between different neurons involved in respiratory function, the study aims to uncover the mechanisms behind opioid-induced respiratory depression. The researchers will use advanced modeling techniques to simulate how opioids alter the activity and connectivity of these neurons. This work is particularly relevant for understanding the risks associated with opioid use in older adults, who may be more vulnerable to respiratory issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are prescribed opioids for pain management.
Not a fit: Patients who are not using opioids or are younger adults may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety guidelines for opioid use, particularly in older adults, reducing the risk of respiratory depression.
How similar studies have performed: Previous research has shown that understanding the neural mechanisms of respiratory control can lead to significant advancements in managing opioid-related respiratory issues, indicating that this approach has potential for success.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Bolser, Donald C — University of Florida
- Study coordinator: Bolser, Donald C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.