How opioids affect anxiety related to trauma
Opioid-BNST interactions in the regulation of trauma-induced anxiety states
['FUNDING_CAREER'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10804702
This study is looking at how opioids affect a part of the brain that may play a role in anxiety after trauma, with the goal of finding new ways to help people who struggle with anxiety and have used opioids.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10804702 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between opioids and a specific brain region known as the BNST, focusing on how these interactions may influence anxiety states that arise after trauma. The study employs advanced techniques such as slice electrophysiology and in vivo calcium imaging to explore the underlying mechanisms of anxiety in individuals with a history of trauma and opioid use. By understanding these interactions, the research aims to identify potential targets for new treatments that could alleviate anxiety symptoms in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced trauma and are dealing with anxiety or opioid use disorders.
Not a fit: Patients who do not have a history of trauma or opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals suffering from anxiety related to trauma and opioid use.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between opioids and anxiety, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSAS-VIDAL, LUIS EDUARDO — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: ROSAS-VIDAL, LUIS EDUARDO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders