How opioid treatment during pregnancy affects mothers and their babies
The effects of gestational opioid exposure on the maternal brain, behavior and microbiome
This study is looking at how the medication buprenorphine, which helps people with opioid use disorder, affects pregnant women and their journey into motherhood, using a rodent model to learn more about its impact on the mother's brain, behavior, and health of their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11087708 on NIH RePORTER |
What this research studies
This research investigates the impact of buprenorphine, a medication used to treat opioid use disorder, on pregnant women and their transition to motherhood. By using a rodent model, the study aims to understand how buprenorphine influences the maternal brain, behavior, and microbiome, as well as the long-term effects on offspring. The research seeks to fill a critical knowledge gap regarding the effects of opioid treatment on maternal care and the health of children born to mothers with opioid use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women undergoing treatment for opioid use disorder, particularly those using buprenorphine.
Not a fit: Patients who are not pregnant or those not affected by opioid use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for pregnant women with opioid use disorder, enhancing maternal and infant health outcomes.
How similar studies have performed: While there is existing research on opioid effects during pregnancy, this specific investigation into buprenorphine's impact on maternal behavior and microbiome is relatively novel.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Brummelte, Susanne — Wayne State University
- Study coordinator: Brummelte, Susanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.