How older fathers' age affects genetic mutations in their children
The Paternal Age Effect - Enhanced Germ Cell Mutagenesis Modulated by the TRP53/APE1/MDM2 Tumor Suppressor Axis
This study looks at how being an older dad might change the DNA in his sperm and how that could affect his children's health, using mice to learn more about the process and help older fathers understand their reproductive health better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10848364 on NIH RePORTER |
What this research studies
This research investigates how the age of fathers influences the genetic mutations present in their sperm, which can affect the health of their children. It focuses on understanding the mechanisms behind increased mutations in older fathers, particularly looking at specific proteins that play a role in DNA repair. By studying these processes in mice, the research aims to identify how aging impacts sperm quality and the potential risks for genetic diseases in offspring. The findings could lead to better understanding and management of reproductive health in older fathers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include older fathers or prospective fathers who are concerned about the genetic health of their children.
Not a fit: Patients who are younger fathers or those who do not plan to have children may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could help identify risks associated with older paternal age and improve genetic counseling for families considering having children later in life.
How similar studies have performed: Previous research has indicated a correlation between paternal age and increased genetic mutations, suggesting that this area of study is both relevant and necessary for further exploration.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Kraig, Ellen — University of Texas Hlth Science Center
- Study coordinator: Kraig, Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.